New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition.
Identifieur interne : 000620 ( Main/Exploration ); précédent : 000619; suivant : 000621New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition.
Auteurs : Rim Malek [France, Tunisie] ; Raquel L. Arribas [Espagne] ; Alejandra Palomino-Antolin [Espagne] ; Perle Totoson [France] ; Celine Demougeot [France] ; Tereza Kobrlova [République tchèque] ; Ondrej Soukup [République tchèque] ; Isabel Iriepa ; Ignacio Moraleda ; Daniel Diez-Iriepa [Espagne] ; Justyna Gody [Pologne] ; Dawid Panek [Pologne] ; Barbara Malawska [Pologne] ; Monika Głuch-Lutwin [Pologne] ; Barbara Mordyl [Pologne] ; Agata Siwek [Pologne] ; Fakher Chabchoub [Tunisie] ; José Marco-Contelles [Espagne] ; Katarzyna Kiec-Kononowicz [Pologne] ; Javier Egea [Espagne] ; Crist Bal De Los Ríos [Espagne] ; Lhassane Ismaili [France]Source :
- Journal of medicinal chemistry [ 1520-4804 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Anticholinestérasiques (composition chimique), Anticholinestérasiques (pharmacologie), Bibliothèques de petites molécules (composition chimique), Bibliothèques de petites molécules (pharmacologie), Cellules cancéreuses en culture (MeSH), Humains (MeSH), Inhibiteurs des canaux calciques (composition chimique), Inhibiteurs des canaux calciques (pharmacologie), Maladie d'Alzheimer (métabolisme), Maladie d'Alzheimer (traitement médicamenteux), Neuroblastome (métabolisme), Neuroblastome (traitement médicamenteux), Neuroprotecteurs (composition chimique), Neuroprotecteurs (pharmacologie), Récepteur histaminergique H3 (composition chimique), Souris (MeSH), Troubles de la mémoire (métabolisme), Troubles de la mémoire (traitement médicamenteux), Vasodilatateurs (composition chimique), Vasodilatateurs (pharmacologie).
- MESH :
- composition chimique : Anticholinestérasiques, Bibliothèques de petites molécules, Inhibiteurs des canaux calciques, Neuroprotecteurs, Récepteur histaminergique H3, Vasodilatateurs.
- métabolisme : Maladie d'Alzheimer, Neuroblastome, Troubles de la mémoire.
- pharmacologie : Anticholinestérasiques, Bibliothèques de petites molécules, Inhibiteurs des canaux calciques, Neuroprotecteurs, Vasodilatateurs.
- traitement médicamenteux : Maladie d'Alzheimer, Neuroblastome, Troubles de la mémoire.
- Animaux, Cellules cancéreuses en culture, Humains, Souris.
English descriptors
- KwdEn :
- Alzheimer Disease (drug therapy), Alzheimer Disease (metabolism), Animals (MeSH), Calcium Channel Blockers (chemistry), Calcium Channel Blockers (pharmacology), Cholinesterase Inhibitors (chemistry), Cholinesterase Inhibitors (pharmacology), Humans (MeSH), Memory Disorders (drug therapy), Memory Disorders (metabolism), Mice (MeSH), Neuroblastoma (drug therapy), Neuroblastoma (metabolism), Neuroprotective Agents (chemistry), Neuroprotective Agents (pharmacology), Receptors, Histamine H3 (chemistry), Small Molecule Libraries (chemistry), Small Molecule Libraries (pharmacology), Tumor Cells, Cultured (MeSH), Vasodilator Agents (chemistry), Vasodilator Agents (pharmacology).
- MESH :
- chemical , chemistry : Calcium Channel Blockers, Cholinesterase Inhibitors, Neuroprotective Agents, Receptors, Histamine H3, Small Molecule Libraries, Vasodilator Agents.
- drug therapy : Alzheimer Disease, Memory Disorders, Neuroblastoma.
- metabolism : Alzheimer Disease, Memory Disorders, Neuroblastoma.
- chemical , pharmacology : Calcium Channel Blockers, Cholinesterase Inhibitors, Neuroprotective Agents, Small Molecule Libraries, Vasodilator Agents.
- Animals, Humans, Mice, Tumor Cells, Cultured.
Abstract
New tritarget small molecules combining Ca2+ channels blockade, cholinesterase, and H3 receptor inhibition were obtained by multicomponent synthesis. Compound 3p has been identified as a very promising lead, showing good Ca2+ channels blockade activity (IC50 = 21 ± 1 μM), potent affinity against hH3R (Ki = 565 ± 62 nM), a moderate but selective hBuChE inhibition (IC50 = 7.83 ± 0.10 μM), strong antioxidant power (3.6 TE), and ability to restore cognitive impairment induced by lipopolysaccharide.
DOI: 10.1021/acs.jmedchem.9b00937
PubMed: 31724859
Affiliations:
- Espagne, France, Pologne, République tchèque, Tunisie
- Bourgogne-Franche-Comté, Communauté de Madrid, Franche-Comté
- , Besançon , Besançon
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000200
- to stream PubMed, to step Curation: 000199
- to stream PubMed, to step Checkpoint: 000231
- to stream Main, to step Merge: 000620
- to stream Main, to step Curation: 000620
Le document en format XML
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, Université Bourgogne Franche-Comté , F-25030 , Besançon </wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">, Besançon </settlement></placeName></affiliation></author><author><name sortKey="Demougeot, Celine" sort="Demougeot, Celine" uniqKey="Demougeot C" first="Celine" last="Demougeot">Celine Demougeot</name><affiliation wicri:level="3"><nlm:affiliation>EA4267 PEPITE , Université Bourgogne Franche-Comté , F-25030 , Besançon , France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA4267 PEPITE , Université Bourgogne Franche-Comté , F-25030 , Besançon </wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">, Besançon </settlement></placeName></affiliation></author><author><name sortKey="Kobrlova, Tereza" sort="Kobrlova, Tereza" uniqKey="Kobrlova T" first="Tereza" last="Kobrlova">Tereza Kobrlova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , University of Defence , CZ-500 01 Hradec Kralove , Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , University of Defence , CZ-500 01 Hradec Kralove </wicri:regionArea><wicri:noRegion>CZ-500 01 Hradec Kralove </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Biomedical Research Center , University Hospital CZ-500 05 Hradec Kralove , Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Biomedical Research Center , University Hospital CZ-500 05 Hradec Kralove </wicri:regionArea><wicri:noRegion>University Hospital CZ-500 05 Hradec Kralove </wicri:noRegion></affiliation></author><author><name sortKey="Soukup, Ondrej" sort="Soukup, Ondrej" uniqKey="Soukup O" first="Ondrej" last="Soukup">Ondrej Soukup</name><affiliation wicri:level="1"><nlm:affiliation>Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , University of Defence , CZ-500 01 Hradec Kralove , Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , University of Defence , CZ-500 01 Hradec Kralove </wicri:regionArea><wicri:noRegion>CZ-500 01 Hradec Kralove </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Biomedical Research Center , University Hospital CZ-500 05 Hradec Kralove , Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Biomedical Research Center , University Hospital CZ-500 05 Hradec Kralove </wicri:regionArea><wicri:noRegion>University Hospital CZ-500 05 Hradec Kralove </wicri:noRegion></affiliation></author><author><name sortKey="Iriepa, Isabel" sort="Iriepa, Isabel" uniqKey="Iriepa I" first="Isabel" last="Iriepa">Isabel Iriepa</name></author><author><name sortKey="Moraleda, Ignacio" sort="Moraleda, Ignacio" uniqKey="Moraleda I" first="Ignacio" last="Moraleda">Ignacio Moraleda</name></author><author><name sortKey="Diez Iriepa, Daniel" sort="Diez Iriepa, Daniel" uniqKey="Diez Iriepa D" first="Daniel" last="Diez-Iriepa">Daniel Diez-Iriepa</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Medicinal Chemistry, IQOG, CSIC , Juan de la Cierva 3 , 28006 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Laboratory of Medicinal Chemistry, IQOG, CSIC , Juan de la Cierva 3 , 28006 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Gody, Justyna" sort="Gody, Justyna" uniqKey="Gody J" first="Justyna" last="Gody">Justyna Gody</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków </wicri:regionArea><wicri:noRegion>30-688 Kraków </wicri:noRegion></affiliation></author><author><name sortKey="Panek, Dawid" sort="Panek, Dawid" uniqKey="Panek D" first="Dawid" last="Panek">Dawid Panek</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków </wicri:regionArea><wicri:noRegion>30-688 Kraków </wicri:noRegion></affiliation></author><author><name sortKey="Malawska, Barbara" sort="Malawska, Barbara" uniqKey="Malawska B" first="Barbara" last="Malawska">Barbara Malawska</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków </wicri:regionArea><wicri:noRegion>30-688 Kraków </wicri:noRegion></affiliation></author><author><name sortKey="Gluch Lutwin, Monika" sort="Gluch Lutwin, Monika" uniqKey="Gluch Lutwin M" first="Monika" last="Głuch-Lutwin">Monika Głuch-Lutwin</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków </wicri:regionArea><wicri:noRegion>30-688 Kraków </wicri:noRegion></affiliation></author><author><name sortKey="Mordyl, Barbara" sort="Mordyl, Barbara" uniqKey="Mordyl B" first="Barbara" last="Mordyl">Barbara Mordyl</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków </wicri:regionArea><wicri:noRegion>30-688 Kraków </wicri:noRegion></affiliation></author><author><name sortKey="Siwek, Agata" sort="Siwek, Agata" uniqKey="Siwek A" first="Agata" last="Siwek">Agata Siwek</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków </wicri:regionArea><wicri:noRegion>30-688 Kraków </wicri:noRegion></affiliation></author><author><name sortKey="Chabchoub, Fakher" sort="Chabchoub, Fakher" uniqKey="Chabchoub F" first="Fakher" last="Chabchoub">Fakher Chabchoub</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Applied Chemistry: Heterocycles, Lipids and Polymers , University of Sfax , B. P 802, 3000 Sfax , Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Applied Chemistry: Heterocycles, Lipids and Polymers , University of Sfax , B. P 802, 3000 Sfax </wicri:regionArea><wicri:noRegion>3000 Sfax </wicri:noRegion></affiliation></author><author><name sortKey="Marco Contelles, Jose" sort="Marco Contelles, Jose" uniqKey="Marco Contelles J" first="José" last="Marco-Contelles">José Marco-Contelles</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Medicinal Chemistry, IQOG, CSIC , Juan de la Cierva 3 , 28006 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Laboratory of Medicinal Chemistry, IQOG, CSIC , Juan de la Cierva 3 , 28006 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Kiec Kononowicz, Katarzyna" sort="Kiec Kononowicz, Katarzyna" uniqKey="Kiec Kononowicz K" first="Katarzyna" last="Kiec-Kononowicz">Katarzyna Kiec-Kononowicz</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków </wicri:regionArea><wicri:noRegion>30-688 Kraków </wicri:noRegion></affiliation></author><author><name sortKey="Egea, Javier" sort="Egea, Javier" uniqKey="Egea J" first="Javier" last="Egea">Javier Egea</name><affiliation wicri:level="2"><nlm:affiliation>Instituto Teofilo Hernando , Universidad Autónoma de Madrid , C/Arzobispo Morcillo, 4 , 28029 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto Teofilo Hernando , Universidad Autónoma de Madrid , C/Arzobispo Morcillo, 4 , 28029 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Molecular Neuroinflammation and Neuronal Plasticity Laboratory, Research Unit , Hospital Universitario Santa Cristina , 28009 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Molecular Neuroinflammation and Neuronal Plasticity Laboratory, Research Unit , Hospital Universitario Santa Cristina , 28009 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Instituto de Investigación Sanitaria , Hospital Universitario de la Princesa , 28006 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Investigación Sanitaria , Hospital Universitario de la Princesa , 28006 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="De Los Rios, Crist Bal" sort="De Los Rios, Crist Bal" uniqKey="De Los Rios C" first="Crist Bal" last="De Los Ríos">Crist Bal De Los Ríos</name><affiliation wicri:level="2"><nlm:affiliation>Servicio de Farmacología Clínica, Instituto de Investigación Sanitaria , Hospital Universitario de la Princesa , C/Diego de León, 62 , 28006 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Farmacología Clínica, Instituto de Investigación Sanitaria , Hospital Universitario de la Princesa , C/Diego de León, 62 , 28006 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Instituto Teofilo Hernando , Universidad Autónoma de Madrid , C/Arzobispo Morcillo, 4 , 28029 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto Teofilo Hernando , Universidad Autónoma de Madrid , C/Arzobispo Morcillo, 4 , 28029 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Ismaili, Lhassane" sort="Ismaili, Lhassane" uniqKey="Ismaili L" first="Lhassane" last="Ismaili">Lhassane Ismaili</name><affiliation wicri:level="3"><nlm:affiliation>Neurosciences Intégratives et Cliniques EA 481, Pôle de Chimie Organique et Thérapeutique , Université Bourgogne Franche-Comté, UFR Santé , 19, Rue Ambroise Paré , F-25000 Besançon , France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Intégratives et Cliniques EA 481, Pôle de Chimie Organique et Thérapeutique , Université Bourgogne Franche-Comté, UFR Santé , 19, Rue Ambroise Paré , F-25000 Besançon </wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon </settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31724859</idno><idno type="pmid">31724859</idno><idno type="doi">10.1021/acs.jmedchem.9b00937</idno><idno type="wicri:Area/PubMed/Corpus">000200</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000200</idno><idno type="wicri:Area/PubMed/Curation">000199</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000199</idno><idno type="wicri:Area/PubMed/Checkpoint">000231</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000231</idno><idno type="wicri:Area/Main/Merge">000620</idno><idno type="wicri:Area/Main/Curation">000620</idno><idno type="wicri:Area/Main/Exploration">000620</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H<sub>3</sub> Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition.</title><author><name sortKey="Malek, Rim" sort="Malek, Rim" uniqKey="Malek R" first="Rim" last="Malek">Rim Malek</name><affiliation wicri:level="3"><nlm:affiliation>Neurosciences Intégratives et Cliniques EA 481, Pôle de Chimie Organique et Thérapeutique , Université Bourgogne Franche-Comté, UFR Santé , 19, Rue Ambroise Paré , F-25000 Besançon , France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Intégratives et Cliniques EA 481, Pôle de Chimie Organique et Thérapeutique , Université Bourgogne Franche-Comté, UFR Santé , 19, Rue Ambroise Paré , F-25000 Besançon </wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon </settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Applied Chemistry: Heterocycles, Lipids and Polymers , University of Sfax , B. P 802, 3000 Sfax , Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Applied Chemistry: Heterocycles, Lipids and Polymers , University of Sfax , B. P 802, 3000 Sfax </wicri:regionArea><wicri:noRegion>3000 Sfax </wicri:noRegion></affiliation></author><author><name sortKey="Arribas, Raquel L" sort="Arribas, Raquel L" uniqKey="Arribas R" first="Raquel L" last="Arribas">Raquel L. Arribas</name><affiliation wicri:level="2"><nlm:affiliation>Servicio de Farmacología Clínica, Instituto de Investigación Sanitaria , Hospital Universitario de la Princesa , C/Diego de León, 62 , 28006 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Farmacología Clínica, Instituto de Investigación Sanitaria , Hospital Universitario de la Princesa , C/Diego de León, 62 , 28006 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Instituto Teofilo Hernando , Universidad Autónoma de Madrid , C/Arzobispo Morcillo, 4 , 28029 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto Teofilo Hernando , Universidad Autónoma de Madrid , C/Arzobispo Morcillo, 4 , 28029 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Palomino Antolin, Alejandra" sort="Palomino Antolin, Alejandra" uniqKey="Palomino Antolin A" first="Alejandra" last="Palomino-Antolin">Alejandra Palomino-Antolin</name><affiliation wicri:level="2"><nlm:affiliation>Instituto Teofilo Hernando , Universidad Autónoma de Madrid , C/Arzobispo Morcillo, 4 , 28029 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto Teofilo Hernando , Universidad Autónoma de Madrid , C/Arzobispo Morcillo, 4 , 28029 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Molecular Neuroinflammation and Neuronal Plasticity Laboratory, Research Unit , Hospital Universitario Santa Cristina , 28009 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Molecular Neuroinflammation and Neuronal Plasticity Laboratory, Research Unit , Hospital Universitario Santa Cristina , 28009 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Instituto de Investigación Sanitaria , Hospital Universitario de la Princesa , 28006 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Investigación Sanitaria , Hospital Universitario de la Princesa , 28006 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Totoson, Perle" sort="Totoson, Perle" uniqKey="Totoson P" first="Perle" last="Totoson">Perle Totoson</name><affiliation wicri:level="3"><nlm:affiliation>EA4267 PEPITE , Université Bourgogne Franche-Comté , F-25030 , Besançon , France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA4267 PEPITE , Université Bourgogne Franche-Comté , F-25030 , Besançon </wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">, Besançon </settlement></placeName></affiliation></author><author><name sortKey="Demougeot, Celine" sort="Demougeot, Celine" uniqKey="Demougeot C" first="Celine" last="Demougeot">Celine Demougeot</name><affiliation wicri:level="3"><nlm:affiliation>EA4267 PEPITE , Université Bourgogne Franche-Comté , F-25030 , Besançon , France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA4267 PEPITE , Université Bourgogne Franche-Comté , F-25030 , Besançon </wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">, Besançon </settlement></placeName></affiliation></author><author><name sortKey="Kobrlova, Tereza" sort="Kobrlova, Tereza" uniqKey="Kobrlova T" first="Tereza" last="Kobrlova">Tereza Kobrlova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , University of Defence , CZ-500 01 Hradec Kralove , Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , University of Defence , CZ-500 01 Hradec Kralove </wicri:regionArea><wicri:noRegion>CZ-500 01 Hradec Kralove </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Biomedical Research Center , University Hospital CZ-500 05 Hradec Kralove , Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Biomedical Research Center , University Hospital CZ-500 05 Hradec Kralove </wicri:regionArea><wicri:noRegion>University Hospital CZ-500 05 Hradec Kralove </wicri:noRegion></affiliation></author><author><name sortKey="Soukup, Ondrej" sort="Soukup, Ondrej" uniqKey="Soukup O" first="Ondrej" last="Soukup">Ondrej Soukup</name><affiliation wicri:level="1"><nlm:affiliation>Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , University of Defence , CZ-500 01 Hradec Kralove , Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , University of Defence , CZ-500 01 Hradec Kralove </wicri:regionArea><wicri:noRegion>CZ-500 01 Hradec Kralove </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Biomedical Research Center , University Hospital CZ-500 05 Hradec Kralove , Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Biomedical Research Center , University Hospital CZ-500 05 Hradec Kralove </wicri:regionArea><wicri:noRegion>University Hospital CZ-500 05 Hradec Kralove </wicri:noRegion></affiliation></author><author><name sortKey="Iriepa, Isabel" sort="Iriepa, Isabel" uniqKey="Iriepa I" first="Isabel" last="Iriepa">Isabel Iriepa</name></author><author><name sortKey="Moraleda, Ignacio" sort="Moraleda, Ignacio" uniqKey="Moraleda I" first="Ignacio" last="Moraleda">Ignacio Moraleda</name></author><author><name sortKey="Diez Iriepa, Daniel" sort="Diez Iriepa, Daniel" uniqKey="Diez Iriepa D" first="Daniel" last="Diez-Iriepa">Daniel Diez-Iriepa</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Medicinal Chemistry, IQOG, CSIC , Juan de la Cierva 3 , 28006 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Laboratory of Medicinal Chemistry, IQOG, CSIC , Juan de la Cierva 3 , 28006 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Gody, Justyna" sort="Gody, Justyna" uniqKey="Gody J" first="Justyna" last="Gody">Justyna Gody</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków </wicri:regionArea><wicri:noRegion>30-688 Kraków </wicri:noRegion></affiliation></author><author><name sortKey="Panek, Dawid" sort="Panek, Dawid" uniqKey="Panek D" first="Dawid" last="Panek">Dawid Panek</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków </wicri:regionArea><wicri:noRegion>30-688 Kraków </wicri:noRegion></affiliation></author><author><name sortKey="Malawska, Barbara" sort="Malawska, Barbara" uniqKey="Malawska B" first="Barbara" last="Malawska">Barbara Malawska</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków </wicri:regionArea><wicri:noRegion>30-688 Kraków </wicri:noRegion></affiliation></author><author><name sortKey="Gluch Lutwin, Monika" sort="Gluch Lutwin, Monika" uniqKey="Gluch Lutwin M" first="Monika" last="Głuch-Lutwin">Monika Głuch-Lutwin</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków </wicri:regionArea><wicri:noRegion>30-688 Kraków </wicri:noRegion></affiliation></author><author><name sortKey="Mordyl, Barbara" sort="Mordyl, Barbara" uniqKey="Mordyl B" first="Barbara" last="Mordyl">Barbara Mordyl</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków </wicri:regionArea><wicri:noRegion>30-688 Kraków </wicri:noRegion></affiliation></author><author><name sortKey="Siwek, Agata" sort="Siwek, Agata" uniqKey="Siwek A" first="Agata" last="Siwek">Agata Siwek</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków </wicri:regionArea><wicri:noRegion>30-688 Kraków </wicri:noRegion></affiliation></author><author><name sortKey="Chabchoub, Fakher" sort="Chabchoub, Fakher" uniqKey="Chabchoub F" first="Fakher" last="Chabchoub">Fakher Chabchoub</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Applied Chemistry: Heterocycles, Lipids and Polymers , University of Sfax , B. P 802, 3000 Sfax , Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Applied Chemistry: Heterocycles, Lipids and Polymers , University of Sfax , B. P 802, 3000 Sfax </wicri:regionArea><wicri:noRegion>3000 Sfax </wicri:noRegion></affiliation></author><author><name sortKey="Marco Contelles, Jose" sort="Marco Contelles, Jose" uniqKey="Marco Contelles J" first="José" last="Marco-Contelles">José Marco-Contelles</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Medicinal Chemistry, IQOG, CSIC , Juan de la Cierva 3 , 28006 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Laboratory of Medicinal Chemistry, IQOG, CSIC , Juan de la Cierva 3 , 28006 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Kiec Kononowicz, Katarzyna" sort="Kiec Kononowicz, Katarzyna" uniqKey="Kiec Kononowicz K" first="Katarzyna" last="Kiec-Kononowicz">Katarzyna Kiec-Kononowicz</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy , Jagiellonian University Medical College , Medyczna 9 , 30-688 Kraków </wicri:regionArea><wicri:noRegion>30-688 Kraków </wicri:noRegion></affiliation></author><author><name sortKey="Egea, Javier" sort="Egea, Javier" uniqKey="Egea J" first="Javier" last="Egea">Javier Egea</name><affiliation wicri:level="2"><nlm:affiliation>Instituto Teofilo Hernando , Universidad Autónoma de Madrid , C/Arzobispo Morcillo, 4 , 28029 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto Teofilo Hernando , Universidad Autónoma de Madrid , C/Arzobispo Morcillo, 4 , 28029 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Molecular Neuroinflammation and Neuronal Plasticity Laboratory, Research Unit , Hospital Universitario Santa Cristina , 28009 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Molecular Neuroinflammation and Neuronal Plasticity Laboratory, Research Unit , Hospital Universitario Santa Cristina , 28009 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Instituto de Investigación Sanitaria , Hospital Universitario de la Princesa , 28006 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Investigación Sanitaria , Hospital Universitario de la Princesa , 28006 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="De Los Rios, Crist Bal" sort="De Los Rios, Crist Bal" uniqKey="De Los Rios C" first="Crist Bal" last="De Los Ríos">Crist Bal De Los Ríos</name><affiliation wicri:level="2"><nlm:affiliation>Servicio de Farmacología Clínica, Instituto de Investigación Sanitaria , Hospital Universitario de la Princesa , C/Diego de León, 62 , 28006 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Farmacología Clínica, Instituto de Investigación Sanitaria , Hospital Universitario de la Princesa , C/Diego de León, 62 , 28006 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Instituto Teofilo Hernando , Universidad Autónoma de Madrid , C/Arzobispo Morcillo, 4 , 28029 Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto Teofilo Hernando , Universidad Autónoma de Madrid , C/Arzobispo Morcillo, 4 , 28029 Madrid </wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Ismaili, Lhassane" sort="Ismaili, Lhassane" uniqKey="Ismaili L" first="Lhassane" last="Ismaili">Lhassane Ismaili</name><affiliation wicri:level="3"><nlm:affiliation>Neurosciences Intégratives et Cliniques EA 481, Pôle de Chimie Organique et Thérapeutique , Université Bourgogne Franche-Comté, UFR Santé , 19, Rue Ambroise Paré , F-25000 Besançon , France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Intégratives et Cliniques EA 481, Pôle de Chimie Organique et Thérapeutique , Université Bourgogne Franche-Comté, UFR Santé , 19, Rue Ambroise Paré , F-25000 Besançon </wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon </settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of medicinal chemistry</title><idno type="eISSN">1520-4804</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (drug therapy)</term><term>Alzheimer Disease (metabolism)</term><term>Animals (MeSH)</term><term>Calcium Channel Blockers (chemistry)</term><term>Calcium Channel Blockers (pharmacology)</term><term>Cholinesterase Inhibitors (chemistry)</term><term>Cholinesterase Inhibitors (pharmacology)</term><term>Humans (MeSH)</term><term>Memory Disorders (drug therapy)</term><term>Memory Disorders (metabolism)</term><term>Mice (MeSH)</term><term>Neuroblastoma (drug therapy)</term><term>Neuroblastoma (metabolism)</term><term>Neuroprotective Agents (chemistry)</term><term>Neuroprotective Agents (pharmacology)</term><term>Receptors, Histamine H3 (chemistry)</term><term>Small Molecule Libraries (chemistry)</term><term>Small Molecule Libraries (pharmacology)</term><term>Tumor Cells, Cultured (MeSH)</term><term>Vasodilator Agents (chemistry)</term><term>Vasodilator Agents (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Anticholinestérasiques (composition chimique)</term><term>Anticholinestérasiques (pharmacologie)</term><term>Bibliothèques de petites molécules (composition chimique)</term><term>Bibliothèques de petites molécules (pharmacologie)</term><term>Cellules cancéreuses en culture (MeSH)</term><term>Humains (MeSH)</term><term>Inhibiteurs des canaux calciques (composition chimique)</term><term>Inhibiteurs des canaux calciques (pharmacologie)</term><term>Maladie d'Alzheimer (métabolisme)</term><term>Maladie d'Alzheimer (traitement médicamenteux)</term><term>Neuroblastome (métabolisme)</term><term>Neuroblastome (traitement médicamenteux)</term><term>Neuroprotecteurs (composition chimique)</term><term>Neuroprotecteurs (pharmacologie)</term><term>Récepteur histaminergique H3 (composition chimique)</term><term>Souris (MeSH)</term><term>Troubles de la mémoire (métabolisme)</term><term>Troubles de la mémoire (traitement médicamenteux)</term><term>Vasodilatateurs (composition chimique)</term><term>Vasodilatateurs (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Calcium Channel Blockers</term><term>Cholinesterase Inhibitors</term><term>Neuroprotective Agents</term><term>Receptors, Histamine H3</term><term>Small Molecule Libraries</term><term>Vasodilator Agents</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Anticholinestérasiques</term><term>Bibliothèques de petites molécules</term><term>Inhibiteurs des canaux calciques</term><term>Neuroprotecteurs</term><term>Récepteur histaminergique H3</term><term>Vasodilatateurs</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Alzheimer Disease</term><term>Memory Disorders</term><term>Neuroblastoma</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alzheimer Disease</term><term>Memory Disorders</term><term>Neuroblastoma</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Maladie d'Alzheimer</term><term>Neuroblastome</term><term>Troubles de la mémoire</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anticholinestérasiques</term><term>Bibliothèques de petites molécules</term><term>Inhibiteurs des canaux calciques</term><term>Neuroprotecteurs</term><term>Vasodilatateurs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Calcium Channel Blockers</term><term>Cholinesterase Inhibitors</term><term>Neuroprotective Agents</term><term>Small Molecule Libraries</term><term>Vasodilator Agents</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladie d'Alzheimer</term><term>Neuroblastome</term><term>Troubles de la mémoire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Mice</term><term>Tumor Cells, Cultured</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cancéreuses en culture</term><term>Humains</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">New tritarget small molecules combining Ca<sup>2+</sup> channels blockade, cholinesterase, and H3 receptor inhibition were obtained by multicomponent synthesis. Compound <b>3p</b> has been identified as a very promising lead, showing good Ca<sup>2+</sup> channels blockade activity (IC<sub>50</sub> = 21 ± 1 μM), potent affinity against hH3R (<i>K</i><sub>i</sub> = 565 ± 62 nM), a moderate but selective hBuChE inhibition (IC<sub>50</sub> = 7.83 ± 0.10 μM), strong antioxidant power (3.6 TE), and ability to restore cognitive impairment induced by lipopolysaccharide.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>France</li><li>Pologne</li><li>République tchèque</li><li>Tunisie</li></country><region><li>Bourgogne-Franche-Comté</li><li>Communauté de Madrid</li><li>Franche-Comté</li></region><settlement><li>, Besançon </li><li>Besançon </li></settlement></list><tree><noCountry><name sortKey="Iriepa, Isabel" sort="Iriepa, Isabel" uniqKey="Iriepa I" first="Isabel" last="Iriepa">Isabel Iriepa</name><name sortKey="Moraleda, Ignacio" sort="Moraleda, Ignacio" uniqKey="Moraleda I" first="Ignacio" last="Moraleda">Ignacio Moraleda</name></noCountry><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Malek, Rim" sort="Malek, Rim" uniqKey="Malek R" first="Rim" last="Malek">Rim Malek</name></region><name sortKey="Demougeot, Celine" sort="Demougeot, Celine" uniqKey="Demougeot C" first="Celine" last="Demougeot">Celine Demougeot</name><name sortKey="Ismaili, Lhassane" sort="Ismaili, Lhassane" uniqKey="Ismaili L" first="Lhassane" last="Ismaili">Lhassane Ismaili</name><name sortKey="Totoson, Perle" sort="Totoson, Perle" uniqKey="Totoson P" first="Perle" last="Totoson">Perle Totoson</name></country><country name="Tunisie"><noRegion><name sortKey="Malek, Rim" sort="Malek, Rim" uniqKey="Malek R" first="Rim" last="Malek">Rim Malek</name></noRegion><name sortKey="Chabchoub, Fakher" sort="Chabchoub, Fakher" uniqKey="Chabchoub F" first="Fakher" last="Chabchoub">Fakher Chabchoub</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Arribas, Raquel L" sort="Arribas, Raquel L" uniqKey="Arribas R" first="Raquel L" last="Arribas">Raquel L. Arribas</name></region><name sortKey="Arribas, Raquel L" sort="Arribas, Raquel L" uniqKey="Arribas R" first="Raquel L" last="Arribas">Raquel L. Arribas</name><name sortKey="De Los Rios, Crist Bal" sort="De Los Rios, Crist Bal" uniqKey="De Los Rios C" first="Crist Bal" last="De Los Ríos">Crist Bal De Los Ríos</name><name sortKey="De Los Rios, Crist Bal" sort="De Los Rios, Crist Bal" uniqKey="De Los Rios C" first="Crist Bal" last="De Los Ríos">Crist Bal De Los Ríos</name><name sortKey="Diez Iriepa, Daniel" sort="Diez Iriepa, Daniel" uniqKey="Diez Iriepa D" first="Daniel" last="Diez-Iriepa">Daniel Diez-Iriepa</name><name sortKey="Egea, Javier" sort="Egea, Javier" uniqKey="Egea J" first="Javier" last="Egea">Javier Egea</name><name sortKey="Egea, Javier" sort="Egea, Javier" uniqKey="Egea J" first="Javier" last="Egea">Javier Egea</name><name sortKey="Egea, Javier" sort="Egea, Javier" uniqKey="Egea J" first="Javier" last="Egea">Javier Egea</name><name sortKey="Marco Contelles, Jose" sort="Marco Contelles, Jose" uniqKey="Marco Contelles J" first="José" last="Marco-Contelles">José Marco-Contelles</name><name sortKey="Palomino Antolin, Alejandra" sort="Palomino Antolin, Alejandra" uniqKey="Palomino Antolin A" first="Alejandra" last="Palomino-Antolin">Alejandra Palomino-Antolin</name><name sortKey="Palomino Antolin, Alejandra" sort="Palomino Antolin, Alejandra" uniqKey="Palomino Antolin A" first="Alejandra" last="Palomino-Antolin">Alejandra Palomino-Antolin</name><name sortKey="Palomino Antolin, Alejandra" sort="Palomino Antolin, Alejandra" uniqKey="Palomino Antolin A" first="Alejandra" last="Palomino-Antolin">Alejandra Palomino-Antolin</name></country><country name="République tchèque"><noRegion><name sortKey="Kobrlova, Tereza" sort="Kobrlova, Tereza" uniqKey="Kobrlova T" first="Tereza" last="Kobrlova">Tereza Kobrlova</name></noRegion><name sortKey="Kobrlova, Tereza" sort="Kobrlova, Tereza" uniqKey="Kobrlova T" first="Tereza" last="Kobrlova">Tereza Kobrlova</name><name sortKey="Soukup, Ondrej" sort="Soukup, Ondrej" uniqKey="Soukup O" first="Ondrej" last="Soukup">Ondrej Soukup</name><name sortKey="Soukup, Ondrej" sort="Soukup, Ondrej" uniqKey="Soukup O" first="Ondrej" last="Soukup">Ondrej Soukup</name></country><country name="Pologne"><noRegion><name sortKey="Gody, Justyna" sort="Gody, Justyna" uniqKey="Gody J" first="Justyna" last="Gody">Justyna Gody</name></noRegion><name sortKey="Gluch Lutwin, Monika" sort="Gluch Lutwin, Monika" uniqKey="Gluch Lutwin M" first="Monika" last="Głuch-Lutwin">Monika Głuch-Lutwin</name><name sortKey="Kiec Kononowicz, Katarzyna" sort="Kiec Kononowicz, Katarzyna" uniqKey="Kiec Kononowicz K" first="Katarzyna" last="Kiec-Kononowicz">Katarzyna Kiec-Kononowicz</name><name sortKey="Malawska, Barbara" sort="Malawska, Barbara" uniqKey="Malawska B" first="Barbara" last="Malawska">Barbara Malawska</name><name sortKey="Mordyl, Barbara" sort="Mordyl, Barbara" uniqKey="Mordyl B" first="Barbara" last="Mordyl">Barbara Mordyl</name><name sortKey="Panek, Dawid" sort="Panek, Dawid" uniqKey="Panek D" first="Dawid" last="Panek">Dawid Panek</name><name sortKey="Siwek, Agata" sort="Siwek, Agata" uniqKey="Siwek A" first="Agata" last="Siwek">Agata Siwek</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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